期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 46, 期 5, 页码 2021-2028出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.2889
关键词
reactive oxygen species; nuclear factor-kappa B; tumor invasion; Romo1; oxidative stress
类别
资金
- National Research Foundation of Korea (NRF) - Korean government [NRF-2012R1A2A2A01045800, NRF-2013R1A1A2063171]
- National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea [1020180]
- Korea Health Promotion Institute [1020180] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romol) expression has been reported to increase invasive potential and constitutive activation of nuclear factor-kappa B (NF-kappa B) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF-kappa B activation due to Romol expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress-induced invasion is mediated by Romol expression. The Romol-induced increase of invasive activity was blocked by an inhibitor of kappa B kinase (IKK). These tesults demonstrate that tumor cell invasion in response to oxidative stress is associated with Romol expression and the NF-kappa B signaling pathway. Romol is therefore a promising therapeutic target for diseases characterized by NF-kappa B deregulation.
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