期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 204, 期 2, 页码 239-243出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20070104
关键词
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Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting anti inflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4(+) T cells produce both interferon (IFN)-gamma, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens.
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