期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 2, 页码 483-487出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201306831
关键词
bioconversion; enzymatic catalysis; nanoparticles; polymer brushes; stimuli-responsive materials
资金
- NSF [CBET 0966526, CBET 0966574]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0966574] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1426404] Funding Source: National Science Foundation
The enzymogel nanoparticle made of a magnetic core and polymer brush shell demonstrates a novel type of remote controlled phase-boundary biocatalysis that involves remotely directed binding to and engulfing insoluble substrates, high mobility, and stability of the catalytic centers. The mobile enzymes reside in the polymer brush scaffold and shuttle between the enzymogel interior and surface of the engulfed substrate in the bioconversion process. Biocatalytic activity of the mobile enzymes is preserved in the enzymogel while the brush-like architecture favors the efficient interfacial interaction when the enzymogel spreads over the substrate and extends substantially the reaction area as compared with rigid particles.
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