期刊
CARBOHYDRATE RESEARCH
卷 342, 期 3-4, 页码 643-647出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2006.09.017
关键词
Shigella; Flexneri; LPS; O-acetylation; O-specific chain
资金
- Intramural NIH HHS [Z99 HD999999] Funding Source: Medline
Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. [GRAPHICS] (c) 2006 Elsevier Ltd. All rights reserved.
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