期刊
JOURNAL OF NEUROSCIENCE
卷 27, 期 9, 页码 2349-2356出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5587-06.2007
关键词
fMRI; functional connectivity; anterior cingulate; insula; salience; anxiety
资金
- NCRR NIH HHS [M01 RR000070, P41 RR009784, RR009784, RR000070] Funding Source: Medline
- NIA NIH HHS [K08 AG027086, K08 AG027086-01] Funding Source: Medline
- NICHD NIH HHS [R01 HD047520, HD047520] Funding Source: Medline
- NIMH NIH HHS [MH050604, T32 MH019938, MH019938, R01 MH050604] Funding Source: Medline
- NINDS NIH HHS [K23 NS048302, NS048302, K23 NS048302-03] Funding Source: Medline
Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a salience network, anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an executive-control network that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.
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