期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 2, 页码 595-598出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201307207
关键词
biosynthesis; enzyme catalysis; enzyme inhibitors; molecular switches; photochromism
资金
- Cusanuswerk
- Deutsche Forschungsgemeinschaft [GRK 1910]
The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged inhibitors based on the dithienylethene scaffold were designed utilizing mtPriA's natural rotational symmetry. Switching from the flexible, ring-open to the rigid, ring-closed isomer reduces inhibition activity by one order of magnitude.
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