期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 2, 页码 507-511出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309207
关键词
asymmetric catalysis; CH activation; cyclopentadienyl ligands; hydroarylation; rhodium
资金
- European Research Council under the European Community [257891]
Metal-catalyzed functionalizations at the ortho position of a directing group have become an efficient bond-forming strategy. A wide range of transformations that employ Cp*Rh-III catalysts have been described, but despite their synthetic potential, enantioselective variants that use chiral versions of the Cp* ligand remain scarce (Cp*=pentamethyl cyclopentadienyl). Cyclopentadienyl compounds with an atropchiral biaryl backbone are shown to be suitable ligands for the efficient intramolecular enantioselective hydroarylation of aryl hydroxamates. Dihydrofurans that bear methyl-substituted quaternary stereocenters are thus obtained by CH functionalization under mild conditions.
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