期刊
JOURNAL OF ANTIBIOTICS
卷 60, 期 3, 页码 211-215出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2007.25
关键词
angucyclinone; Nocardia mediterranei subsp kanglensis 1747-64; chemomicin A; SF2315B; structural elucidation
A new angucyclinone antibiotic, chemomicin A was isolated from cultured broth of Nocardia mediterranei subsp. kanglensis 1747-64. Its chemical structure was determined to be 1,2,3,4a,5,6,6a,12a,12b-nonahydro-1,2,3,8,12,12b-hexahydroxy-3-methyl-6a, 12a-epoxybenz[a]anthracen-4,7(12H)-dione by a detailed spectroscopic analysis. Chemomicin A had antimicrobial activity against Bacillus subtilis and Enterococcus faecium with MIC values of 10.2 and 20.4 mu M, respectively, and showed cytotoxicity against human colorectal cancerHCTI 16 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 mu M, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据