期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 49, 期 3, 页码 122-130出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e31802f5895
关键词
3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitors; nitric oxide; tetrahydrobiopterin; angiotensin II; insulin resistance; endothelium
3-Hydroxyl-3-methylglutaryl coenzyme A reductase inhibitors (statins) may benefit the vasculopathy of insulin resistance independent of its lipid-lowering effects. Because imbalance of nitric oxide (NO) and superoxide anion (O-2(-)) formation may lead to vascular dysfunction, we investigated the effect of statin on vasomotion of insulin-resistant state to clarify the mechanism by which statin ameliorates the impaired function. In the isolated aorta, contraction induced by angiotensin 11 was more potent in Zucker fatty rats (ZF) compared with that in Zucker lean rats. Both angiotensin II type I receptor expression and O-2(-) production were upregulated in ZE In addition, deficiency of tetrahydrobiopterin (BH4) contributes to the endothelial dysfunction in ZE Oral administration of pitavastatin for 8 weeks normalized angiotensin II-induced vasoconstriction and endothelial function in ZE Pitavastatin treatment of ZF increased vascular BH4 content, which was associated with twofold increase in endothelial NO synthase (eNOS) activity as well as a 60% reduction in endothelial O-2(-) production. The treatment also markedly downregulated protein expression of angiotensin II type I receptor and gp91phox, whereas expression of guanosine triphosphate cyclohydrolase I was upregulated. Pitavastatin restores vascular dysfunction by inhibiting NAD(P)H oxidase activity and uncoupled eNOS-dependent O-2(-) production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据