期刊
NATURE METHODS
卷 4, 期 3, 页码 219-222出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth1018
关键词
-
资金
- NHLBI NIH HHS [T32 HL07824, R01 HL69438, R01 HL069438] Funding Source: Medline
We present a simple method to identify the recruitment of leukocyte subsets and determine concurrent surface-receptor clustering in live mice. We show that CD45(+) F4/80-Gr-1(+) neutrophils are robustly recruited in surgery-activated cremasteric venules, whereas adherent CD45(+) B220(+) B lymphocytes were dominant in bone marrow venules. Most adherent Gr-1(+) leukocytes are not firmly stationary but actively migrate on TNF-alpha-activated cremasteric venular endothelium and exhibit marked polarization of surface PSGL-1, but not LFA-1, to the trailing edge.
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