相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects
M. A. Hurchla et al.
LEUKEMIA (2013)
Hydroxyureas as Noncovalent Proteasome Inhibitors
Nerea Gallastegui et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Inhibitors for the Immuno- and Constitutive Proteasome: Current and Future Trends in Drug Development
Eva Maria Huber et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
A meta-analysis on alcohol drinking and gastric cancer risk
I. Tramacere et al.
ANNALS OF ONCOLOGY (2012)
A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
The Hien Pham et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Serendipity in discovery of proteasome inhibitors
Derek Dunn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
Eva M. Huber et al.
CELL (2012)
The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium
Alban R. Pereira et al.
CHEMBIOCHEM (2012)
Exploiting nature's rich source of proteasome inhibitors as starting points in drug development
Melissa Ann Graewert et al.
CHEMICAL COMMUNICATIONS (2012)
Proteasome Inhibitors: An Expanding Army Attacking a Unique Target
Alexei F. Kisselev et al.
CHEMISTRY & BIOLOGY (2012)
Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme
Elke Krueger et al.
CURRENT OPINION IN IMMUNOLOGY (2012)
Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE
Matthew M. Seavey et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2012)
Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
Wen-Bo Wang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
Proteomic Profiling of Germ Cell Cancer Cells Treated with Aaptamine, a Marine Alkaloid with Antiproliferative Activity
Sergey A. Dyshlovoy et al.
JOURNAL OF PROTEOME RESEARCH (2012)
Cationic Porphyrins Are Reversible Proteasome Inhibitors
Anna Maria Santoro et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin
Donghui Wei et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Synthesis and biological activity of simplified belactosin C analogues
Armin de Meijere et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones
Wouter A. van der Linden et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Stereoselective Synthesis of Deuterium-Labeled (2S)-Cyclohexenyl Alanines, Biosynthetic Intermediates of Cinnabaramide
Philipp Barbie et al.
ORGANIC LETTERS (2012)
Suberitine A-D, Four New Cytotoxic Dimeric Aaptamine Alkaloids from the Marine Sponge Aaptos suberitoides
Caixia Liu et al.
ORGANIC LETTERS (2012)
Syringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma
John Opoku-Ansah et al.
PHARMACEUTICAL BIOLOGY (2012)
Stereoselective functionalization of pyrrolidinone moiety towards the synthesis of salinosporamide A
Julien Barbion et al.
TETRAHEDRON (2012)
Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
Melissa Ann Graewert et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast
Makoah N. Aminake et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea
Bret Bannerman et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells
Subhasree Roy Choudhury et al.
CARCINOGENESIS (2011)
The role of the proteasome in the generation of MHC class I ligands and immune responses
E. J. A. M. Sijts et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity
Jerome Clerc et al.
CHEMICAL COMMUNICATIONS (2011)
Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib
Anne C. Mirabella et al.
CHEMISTRY & BIOLOGY (2011)
Total Synthesis of (-)-Salinosporamide A
Yuji Kaiya et al.
CHEMISTRY-AN ASIAN JOURNAL (2011)
Natural Product Inhibitors of the Ubiquitin-Proteasome Pathway
John S. Schneekloth et al.
CURRENT DRUG TARGETS (2011)
Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes
Haruhi Kamisaki et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2011)
The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)
Daniel Krahn et al.
NATURAL PRODUCT REPORTS (2011)
Synthesis and biological activity of optimized belactosin C congeners
Vadim S. Korotkov et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Total Synthesis of (-)-Salinosporamide A
Nobuhiro Satoh et al.
ORGANIC LETTERS (2011)
Stereoselective Synthesis of Deuterated β-Cyclohexenylserine, a Biosynthetic Intermediate of the Salinosporamides
Jan Deska et al.
ORGANIC LETTERS (2011)
Syntheses and cytotoxicity of syringolin B-based proteasome inhibitors
Tannya R. Ibarra-Rivera et al.
TETRAHEDRON (2011)
Chemical Proteomics Discloses Petrosapongiolide M, an Antiinflammatory Marine Sesterterpene, as a Proteasome Inhibitor
Luigi Margarucci et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Elucidation of the Structure and Intermolecular Interactions of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling
Benjamin Stauch et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Antiplasmodial Thiostrepton Derivatives: Proteasome Inhibitors with a Dual Mode of Action
Sebastian Schoof et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome
Gang Lin et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor
Sachiko Tsukamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
Dharminder Chauhan et al.
BLOOD (2010)
The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan
Eric Sanchez et al.
BRITISH JOURNAL OF HAEMATOLOGY (2010)
Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer
Erik Kupperman et al.
CANCER RESEARCH (2010)
Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress
Ulrike Seifert et al.
CELL (2010)
Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t
Bogdan I. Florea et al.
CHEMISTRY & BIOLOGY (2010)
Synthesis and Biological Characterization of Argyrin F
Leila Bülow et al.
ChemMedChem (2010)
Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells
Shantel E. Walcott et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2010)
Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry
E. Genin et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)
Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
Jerome Clerc et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2010)
AN ENANTIO- AND DIASTEREOCONTROLLED SYNTHESIS OF (-)-SALINOSPORAMIDE A
Yosuke Sato et al.
HETEROCYCLES (2010)
Mode of Action of Epoxyphomalins A and B and Characterization of Related Metabolites from the Marine-Derived Fungus Paraconiothyrium sp.
Ietidal E. Mohamed et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Concise Formal Synthesis of (-)-Salinosporamide A (Marizomib) Using a Regio- and Stereoselective Epoxidation and Reductive Oxirane Ring-Opening Strategy
Taotao Ling et al.
JOURNAL OF ORGANIC CHEMISTRY (2010)
Formal Synthesis of Belactosin A and Hormaomycin via a Diastereoselective Intramolecular Cyclopropanation of an α-Nitro Diazoester
Sebastien F. Vanier et al.
ORGANIC LETTERS (2010)
Total Synthesis of Syringolin A and B
Michael C. Pirrung et al.
ORGANIC LETTERS (2010)
Total Synthesis of Syringolin A
Chunhui Dai et al.
ORGANIC LETTERS (2010)
Apigenin, Chrysin, and Luteolin Selectively Inhibit Chymotrypsin-Like and Trypsin-Like Proteasome Catalytic Activities in Tumor Cells
Yi-Xin Wu et al.
PLANTA MEDICA (2010)
Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB
Yao Dai et al.
PLOS ONE (2010)
Thiopeptide Antibiotic Biosynthesis
Hans-Dieter Arndt et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
Daniel Finley
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors
Encouse B. Golden et al.
BLOOD (2009)
The peptide-semicarbazone S-2209, a representative of a new class of proteasome inhibitors, induces apoptosis and cell growth arrest in multiple myeloma cells
Philipp Baumann et al.
BRITISH JOURNAL OF HAEMATOLOGY (2009)
Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites
Matthew Britton et al.
CHEMISTRY & BIOLOGY (2009)
Proteasome Inhibitors in Cancer Therapy
Ugo Testa
CURRENT DRUG TARGETS (2009)
Targeting the proteasome pathway
Sachiko Tsukamoto et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
Enantioselective Synthesis and Proteasome Inhibition of A-Ring Analogs of (-)-Epigallocatechin Gallate (EGCG), the Active Ingredient of Green Tea Extract
Tak Hang Chan et al.
HETEROCYCLES (2009)
The 26 S Proteasome: From Basic Mechanisms to Drug Targeting
Ami Navon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Spirodiepoxides: Synthesis of Epoxomicinoids
Yue Zhang et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
The persisting challenge of selective and specific proteasome inhibition
Michael Groll et al.
JOURNAL OF PEPTIDE SCIENCE (2009)
A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis
Tony Muchamuel et al.
NATURE MEDICINE (2009)
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
A. Arlt et al.
ONCOGENE (2009)
Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy
Keisuke Yoshida et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2009)
Celastrol potentiates striatal dopamine metabolism and increases cell death under conditions of proteasome inhibition: in vivo and in vitro studies
Tomasz Lenda et al.
PHARMACOLOGICAL REPORTS (2009)
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
Jerome Clerc et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization
Justin R. Struble et al.
TETRAHEDRON (2009)
New synthetic route to access (±) salinosporamide A via an oxazolone-mediated ene-type reaction
Robert A. Mosey et al.
TETRAHEDRON LETTERS (2009)
Entry to heterocycles based on indium-catalyzed Conia-ene reactions: Asymmetric synthesis of (-)-salinosporamide A
Keisuske Takahashi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
Alessandra S. Eustaquio et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Inhibition of proteasome activity by anthocyanins and anthocyanidins
Andrea Dreiseitel et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Physalin B, a novel inhibitor of the ubiquitin-proteasome pathway, triggers NOXA-associated apoptosis
Isabelle Vandenberghe et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives
Li Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Affinity labeling of the proteasome by a belactosin A derived inhibitor
Makoto Hasegawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Argyrin A reveals a critical role for the tumor suppressor protein p27kip1 in mediating antitumor activities in response to proteasome inhibition
Irina Nickeleit et al.
CANCER CELL (2008)
Proteasome inhibition by fellutamide B induces nerve growth factor synthesis
John Hines et al.
CHEMISTRY & BIOLOGY (2008)
Proteasome inhibitors in cancer therapy: Lessons from the first decade
Robert Z. Orlowski et al.
CLINICAL CANCER RESEARCH (2008)
The potential of proteasome inhibitors in cancer therapy
Jan Sterz et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)
Bortezomib in the front-line treatment of multiple myeloma
Paul G. Richardson et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2008)
Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
Rama Rao Manam et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Chemical genetics: Exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors
Kyung Bo Kim et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
Bruce D. Dorsey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Structural Analysis of Spiro β-Lactone Proteasome Inhibitors
Michael Groll et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Asymmetric copper-catalyzed synthesis of α-amino boronate esters from N-tert-butanesulfinyl aldimines
Melissa A. Beenen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Michael Groll et al.
NATURE (2008)
Total synthesis of salinosporamide A
Takeo Fukuda et al.
ORGANIC LETTERS (2008)
Formal synthesis of salinosporamide A using a nickel-catalyzed reductive aldol cyclization-lactonization as a key step
Isabel Villanueva Margalef et al.
TETRAHEDRON (2008)
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
Roberto Piva et al.
BLOOD (2008)
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB-regulated gene products
Kwang Seok Ahn et al.
BLOOD (2007)
Gold(I)-Catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes
Ellen C. Minnihan et al.
JOURNAL OF ORGANIC CHEMISTRY (2007)
Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
Susan D. Demo et al.
CANCER RESEARCH (2007)
Linear TMC-95-based proteasome inhibitors
Nicolas Basse et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Enantioselective total synthesis of (-)-salinosporamide A (NPI-0052)
Taotao Ling et al.
ORGANIC LETTERS (2007)
Activities of Z-ajoene against tumour and viral spreading in vitro
Jerome Terrasson et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2007)
Concise total synthesis of (±)-salinosporamide A, (±)-cinnabaramide A, and derivatives via a bis-cyclization process:: Implications for a biosynthetic pathway?
Gil Ma et al.
ORGANIC LETTERS (2007)
Highly efficient Au(I)-catalyzed intramolecular addition of β-ketoamide to unactivated alkenes
Cong-Ying Zhou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue
Tommer Ravid et al.
NATURE CELL BIOLOGY (2007)
A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells
Isao Momose et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)
Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells
Kathrin Plochmann et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
Wei Li et al.
NATURE (2007)
Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica
Laura L. Beer et al.
ORGANIC LETTERS (2007)
Multiple on-resin olefin metathesis to form ring-expanded analogues of the lantibiotic peptide, lacticin 3147 A2
Vijaya R. Pattabiraman et al.
ORGANIC LETTERS (2007)
The tumor proteasome is a primary target for the natural anticancer compound withaferin a isolated from Indian Winter Cherry
Huanjie Yang et al.
MOLECULAR PHARMACOLOGY (2007)
Salinosporamides D-J from the marine actinomycete Salinispora tropica, bromosalinosporamide, and thioester derivatives are potent inhibitors of the 20S proteasome
Katherine A. Reed et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Stereoselective formal synthesis of the potent proteasome inhibitor:: salinosporamide A
Virginie Caubert et al.
TETRAHEDRON LETTERS (2007)
Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts
Di Chen et al.
BREAST CANCER RESEARCH (2007)
Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells
Di Chen et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors
Martijn Verdoes et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2007)
Synthesis of peptide aldehydes
Aline Moulin et al.
JOURNAL OF PEPTIDE SCIENCE (2007)
20S proteasome and its inhibitors: Crystallographic knowledge for drug development
Ljudmila Borissenko et al.
CHEMICAL REVIEWS (2007)
Aqueous phosphoric acid as a mild reagent for deprotection of tert-butyl carbamates, esters, and ethers
Bryan Li et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model
James C. Cusack et al.
CLINICAL CANCER RESEARCH (2006)
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo
Martijn Verdoes et al.
CHEMISTRY & BIOLOGY (2006)
Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: Potential application to choroidal neovascularization
Paola Bargagna-Mohan et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2006)
A concise total synthesis of salinosporamide A
Nicholas P. Mulholland et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog
John S. Schneekloth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
Stacey Ruiz et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor
Virginie Caubert et al.
TETRAHEDRON LETTERS (2006)
TMC-95-based inhibitor design provides evidence for the catalytic versatility of the proteasome
Michael Groll et al.
CHEMISTRY & BIOLOGY (2006)
Celastrol, a triterpene extracted from the Chinese Thunder of God Vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
Huanjie Yang et al.
CANCER RESEARCH (2006)
Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding
M Groll et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Plasmodium falciparum:: The fungal metabolite gliotoxin inhibits proteasome proteolytic activity and exerts a plasmodicidal effect on Plasmodium falciparum
T Hatabu et al.
EXPERIMENTAL PARASITOLOGY (2006)
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
M Groll et al.
STRUCTURE (2006)
Lingering mysteries of ubiquitin-chain assembly
M Hochstrasser
CELL (2006)
Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development
S Tsukamoto et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Amide bond formation and peptide coupling
CAGN Montalbetti et al.
TETRAHEDRON (2005)
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
D Chauhan et al.
CANCER CELL (2005)
7-Hydroxy-3-(4-hydroxybenzyl)chroman and broussonin B:: Neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors
S Tsukamoto et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)
Synthesis and activity of tyropeptin A derivatives as potent and selective inhibitors of mammalian 20S proteasome
I Momose et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)
Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines
HA Braun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica
PG Williams et al.
JOURNAL OF ORGANIC CHEMISTRY (2005)
Dimethylaluminum methyltellurate, a new reagent for the cleavage of hindered methyl esters under exceptionally mild conditions by a novel mechanism
BVS Reddy et al.
TETRAHEDRON LETTERS (2005)
An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition
LR Reddy et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
New synthetic route for the enantioselective total synthesis of salinosporamide A and biologically active analogues
LR Reddy et al.
ORGANIC LETTERS (2005)
Total synthesis of salinosporamide A
A Endo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Structure-activity relationship studies of salinosporamide a (NPI-0052), a novel marine derived proteasome inhibitor
VR Macherla et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
D Chen et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib
CR Berkers et al.
NATURE METHODS (2005)
Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome
I Momose et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
M Rechsteiner et al.
TRENDS IN CELL BIOLOGY (2005)
Intracellular protein degradation: From a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting - (Nobel lecture)
A Ciechanover
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells
B Xu et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2004)
The intramolecular Baylis-Hillman reaction: easy preparation of versatile substrates, facile reactions, and synthetic applications
JE Yeo et al.
CHEMICAL COMMUNICATIONS (2004)
Binding mode of TMC-95A analogues to eukaryotic 20S proteasome
M Kaiser et al.
CHEMBIOCHEM (2004)
A concise, total synthesis of the TMC-95A/B proteasome inhibitors
BK Albrecht et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Polyubiquitin chains: polymeric protein signals
CM Pickart et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Spirodiepoxides in total synthesis: Epoxomicin
S Katukojvala et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
A concise route to (+)-lactacystin
H Ooi et al.
JOURNAL OF ORGANIC CHEMISTRY (2004)
Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR
SN Lin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
A simple stereocontrolled synthesis of salinosporamide A
LR Reddy et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors
M Kaiser et al.
CHEMISTRY & BIODIVERSITY (2004)
Synthesis of macrocyclic peptide analogues of proteasome inhibitor TMC-95A
A Berthelot et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
AF Kisselev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein
A Kazi et al.
BIOCHEMICAL PHARMACOLOGY (2003)
New polyhydroxy sterols:: Proteasome inhibitors from a marine sponge Acanthodendrilla sp.
S Tsukamoto et al.
JOURNAL OF NATURAL PRODUCTS (2003)
The chemistry of cyclopropanols
OG Kulinkovich
CHEMICAL REVIEWS (2003)
Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity
ZQ Yang et al.
CHEMBIOCHEM (2003)
The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting
A Ciechanover
BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
Correlation between pKa and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction:: Discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope
VK Aggarwal et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
A concise formal total synthesis of TMC-95A/B proteasome inhibitors
BK Albrecht et al.
ORGANIC LETTERS (2003)
Total synthesis of TMC-95A
M Inoue et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
RH Feling et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Inhibition of proteasome activity by tyropeptin A in PC12 cells
I Momose et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2002)
Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus
DJ Mergott et al.
ORGANIC LETTERS (2002)
In vitro effects of gliotoxin, a natural proteasome inhibitor, on the infectivity and proteolytic activity of Toxoplasma gondii
A Paugam et al.
PARASITOLOGY RESEARCH (2002)
Syntheses and kinetic evaluation of racemic and optically active 2-benzyl-2-methyl-3,4-epoxybutanoic acids as irreversible inactivators for carboxypeptidase A
M Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
The vinylogous intramolecular Morita-Baylis-Hillman reaction: Synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts
SA Frank et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Total synthesis of the cyclic heptapeptide argyrin B: A new potent inhibitor of T-cell independent antibody formation
SV Ley et al.
ORGANIC LETTERS (2002)
Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp MK993-dF2 -: I.: Taxonomy, isolation, physico-chemical properties and biological activities
S Momose et al.
JOURNAL OF ANTIBIOTICS (2001)
Isolation and structural determination of phepropeptins A, B, C, and D, new proteasome inhibitors, produced by Streptomyces sp.
R Sekizawa et al.
JOURNAL OF ANTIBIOTICS (2001)
Total synthesis of (+)-ambruticin
P Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis-Hillman reaction
Y Iwabuchi et al.
TETRAHEDRON LETTERS (2001)
Stereocontrolled synthesis of the northern part of potent proteasome inhibitor TMC-95A
M Inoue et al.
ORGANIC LETTERS (2001)
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits
BM Kessler et al.
CHEMISTRY & BIOLOGY (2001)
Crystal structure of the 20 S proteasome: TMC-95A complex: A non-covalent proteasome inhibitor
M Groll et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Proteasome inhibitors: from research tools to drug candidates
AF Kisselev et al.
CHEMISTRY & BIOLOGY (2001)
Synthesis of modified peptides with C-terminal α-amino aldehydes
JV Potetinova et al.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2001)
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
T Nazif et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Total synthesis of (+)-epopromycin B and its analogues - studies on the inhibition of cellulose biosynthesis
MR Dobler
TETRAHEDRON LETTERS (2001)
Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors
HS Overkleeft et al.
TETRAHEDRON LETTERS (2000)
Structures of TMC-95A-D:: Novel proteasome inhibitors from Apiospora montagnei Sacc. TC 1093
J Kohno et al.
JOURNAL OF ORGANIC CHEMISTRY (2000)
Crystal structure of epoxomicin:20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasome inhibitors
M Groll et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093 -: Taxonomy, production, isolation, and biological activities
Y Koguchi et al.
JOURNAL OF ANTIBIOTICS (2000)
分享论文
