期刊
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
卷 38, 期 -, 页码 S38-S48出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.injury.2007.02.009
关键词
growth factors; bone morphogenetic proteins; demineralized bone matrix; platelet rich plasma; fracture heating; non-union; spinal fusion
Advances in the understanding of bone repair and improved biotechnology have led to the introduction of new strategies for orthopedic surgeons to control and modulate bone heating using growth factors. However, many orthopedic surgeons are uncertain about the current levels of evidence supporting the use of materials that possess these properties and their therapeutic role in the management of skeletal problems such as fracture, long-bone nonunion, and spine fusion. In particular, the differences amongst osteoinductive factors synthesized by recombinant gene technology, or derived from demineralized bone matrix or platelet rich plasma requires clarification.
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