期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 47, 期 5, 页码 1759-1766出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.3162
关键词
cervical cancer; HPV16 E7; miR-27b; PPAR gamma; NHE1
类别
资金
- National Natural Science Foundation of China [81371901]
- Ministry of Education [20134433110010]
MicroRNAs (miRNAs) have been reported to be involved in multiple biological pathways that can influence tumor progression and metastasis. High-risk human papillomavirus (HR-HPVs) is aetiologically correlated to cervical cancer. Recently, miRNAs were reported to be regulated by virus and play pivotal roles in HPV-related tumor progression. However, the underlying mechanism remains poorly understood. In the present study, we report that HPV16 E7 upregulated miR-27b to promote proliferation and invasion in cervical cancer. The results showed that PPAR gamma, as a target of miR-27b, played a significant role in suppressing cervical cancer progression by downregulating the sodium-hydrogen exchanger isoform 1 (NHE1). It was also shown that the inhibition of miR-27b diminished the ability of HPV16 E7 to suppress PPAR gamma or activate NHE1 expression. In addition, we observed high expression of miR-27b and NHE1, but low expression of PPAR gamma in HPV16-positive cervical cancer tissues. In summary, the present study revealed that miR-27b is upregulated by HPV16 E7 to inhibit PPAR gamma expression and promotes proliferation and invasion in cervical carcinoma cells.
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