期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 1, 页码 305-309出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201307849
关键词
7; 8-dihydro-8-oxoguanosine triphosphatase; enzyme inhibitors; organometallic compounds; protein crystal structures; ruthenium
资金
- German Research Foundation [ME 1805/9-1]
- U.S. National Institutes of Health [CA114046]
The probe-based discovery of the first small-molecule inhibitor of the repair enzyme 8-oxo-dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half-sandwich complex. The organometallic inhibitor with low-nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据