期刊
EXPERIMENTAL NEUROLOGY
卷 204, 期 1, 页码 58-65出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2006.09.015
关键词
fMRI; SCI; cortical plasticity; NT3
资金
- NCRR NIH HHS [S10 RR17205] Funding Source: Medline
- NINDS NIH HHS [R01 NS30821] Funding Source: Medline
Functional magnetic resonance imaging (fMRI) studies were performed for visualizing ongoing brain plasticity in Neurotrophin-3 (NT3)-treated experimental spinal cord injury (SCI). In response to the electrical stimulation of the forepaw, the NT3-treated animals showed extensive activation of brain structures that included contralateral cortex, thalamus, caudate putamen, hippocampus, and periaqueductal gray. Quantitative analysis of the fMRI data indicated significant changes both in the volume and center of activations in NT3-treated animals relative to saline-treated controls. A strong activation in both ipsi- and contralateral periaqueductal gray and thalamus was observed in NT3-treated animals. These studies indicate ongoing brain reorganization in the SCI animals. The fMRI results also suggest that NT3 may influence nociceptive pathways. (c) 2006 Elsevier Inc. All rights reserved.
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