期刊
MEDICAL AND VETERINARY ENTOMOLOGY
卷 21, 期 1, 页码 97-102出版社
WILEY
DOI: 10.1111/j.1365-2915.2007.00671.x
关键词
Anopheles arabiensis; carbamates; DDT; insecticide resistance; kdr mutation; organophosphates; pyrethroids; Sudan
资金
- NIAID NIH HHS [R03 AI059469-01] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
A colony of Anopheles arabiensis Patton (Diptera: Culicidae) from the Sennar region of Sudan was selected for resistance to dichlorodiphenyltrichloroethane (DDT). Adults from the F-16 generation of the resistant strain were exposed to all four classes of insecticides approved for use in malaria vector control and showed high levels of resistance to them all (24-h mortalities: malathion, 16.7%; bendiocarb, 33.3%; DDT, 12.1%; dieldrin, 0%; deltamethrin, 24.0%; permethrin, 0%). Comparisons between the unselected base colony and the DDT-resistant strain showed elevated glutathione-S-transferase (P < 0.05) in both sexes and elevated esterases (P < 0.05) in males only. The Leu-Phe mutation in the sodium channel gene was detected by polymerase chain reaction and sequencing, but showed no correlation with the resistant phenotype. These results do not provide any explanation as to why this colony exhibits such widespread resistance and further studies are needed to determine the precise mechanisms involved. The implications for malaria vector control in central Sudan are serious and resistance management (e.g. through the rotational use of different classes of insecticides) is recommended.
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