期刊
NEUROBIOLOGY OF DISEASE
卷 25, 期 3, 页码 561-570出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2006.10.018
关键词
-
资金
- Intramural NIH HHS Funding Source: Medline
- Medical Research Council [G0701075, G0501560, G0501560(76517)] Funding Source: Medline
- NIA NIH HHS [AG05128, P30-AG13846, AG 05146, AG-17586, P50 AG16570, AG-10124, P50-AG08671] Funding Source: Medline
- NIMH NIH HHS [MH60451] Funding Source: Medline
- NINDS NIH HHS [NS39764] Funding Source: Medline
- Alzheimers Research UK [ART-PhD2007-2] Funding Source: researchfish
- Medical Research Council [G0701075, G0501560] Funding Source: researchfish
- MRC [G0701075, G0501560] Funding Source: UKRI
Previously we have shown that the H1c haplotype on the background of the HI clade of haplotypes at the MAPT locus is associated with increased risk for progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Alzheimer's disease (AD). Here we replicated the association with AD in an additional autopsy confirmed series. We show that this haplotype increases both the expression of total MAPT transcript as well as specifically increasing the proportion of 4 microtubule binding repeat containing transcripts. We discuss these findings both in terms of the problems facing the dissection of the etiologies of complex traits and the pathogenesis of the tauopathies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据