期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 47, 期 3, 页码 315-322出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0091270006297229
关键词
dopoxetine; ethanol; pharmacokinetics; cognition
Dopoxetine is being investigated for the treatment of premature ejaculation. This study evaluated the potential pharmacokinetic and cognitive interactions of dapoxetine 60 mg with ethanol 0.5 g/kg in a single-center, double-blind, randomized, placebo-con trolled crossover study in healthy adult male participants (n = 24). Dapoxetine was rapidly absorbed and eliminated; peak concentrations were noted 1.47 hours after administration and decreased with an alpha half-life of 1.33 hours and a terminal half-life of 15.6 hours. Pharmacokinetic parameters (C-max, AUC(infinity), t(1/2), and t(max)) of dapoxetine were not altered with concurrent ethanol consumption. Furthermore, coadministration of dapoxetine did not affect the pharmacokinetics of ethanol or potentiate the cognitive and subjective effects of ethanol.
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