期刊
ALCOHOL AND ALCOHOLISM
卷 42, 期 2, 页码 158-160出版社
OXFORD UNIV PRESS
DOI: 10.1093/alcalc/agl091
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Aims: To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans. Methods: A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day. Results: The patient reported dramatic reduction in cravings for and preoccupation with alcohol. Conclusions: High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
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