期刊
JOURNAL OF IMMUNOLOGY
卷 178, 期 5, 页码 3023-3030出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.5.3023
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The genomic organization of the chicken CD8 alpha gene was investigated to determine the basis of its polymorphism. Contiguous to the CD8 alpha gene we identified multiple DNA blocks possessing sequences homologous to CD8 alpha. Gene conversions and recombination over evolutionary time among CD8 alpha and these CD8 alpha homologous genes seem to account for the observed polymorphism. Furthermore, these CD8 alpha-like DNAs encode a distinct multigene family of inummoreceptors that have a charged or polar residue in place of the interspecies-conserved CD8 alpha transmembrane proline residue and a short cytoplasmic tail nonhomologous to CD8 alpha. The identification of this novel multigene family with an organization reminiscent of human killer Ig-like receptors raises compelling questions on their evolutionary relationship among immunorecepturs.
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