期刊
EUROPEAN JOURNAL OF CANCER
卷 43, 期 4, 页码 640-646出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.12.005
关键词
anaplastic lymphoma kinase (ALK); anaplastic large cell lymphomas (ALCL); inflammatory myofibroblastic tumours (IMT); X-ALK variants; experimental lung metastasis; actin cytoskeleton
类别
Translocations of the anaplastic lymphoma kinase (ALK) gene result in the production of a number of oncogenic ALK fusion proteins implicated in tumour development. We have previously shown that X-ALK fusion proteins have differential effects on the proliferation, transformation, and invasion properties of NIH3T3 cells in vitro. In the present study, we have investigated the metastatic potential of various X-ALK expressing cell lines using an experimental lung metastasis assay. We have shown that TPM3-ALK expression bestows higher metastatic capacities than other X-ALK fusion proteins and in addition, that TPM3-ALK fusion protein expression specifically induces changes in cell morphology and cytoskeleton Organisation. Co-immunoprecipitation studies demonstrate a specific interaction between TPM3-ALK and endogenous tropomyosin. Together the specific actions of TPM3-ALK on the cytoskeleton Organisation offer an interesting hypothesis with respect to the higher cell motility and metastatic potential of this fusion protein. (c) 2007 Elsevier Ltd. All rights reserved.
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