期刊
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
卷 1, 期 1, 页码 63-72出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2007.893176
关键词
Biomedical instrumentation; correlated double sampling; current measurement; micropower techniques; potentiostat; sigma-delta modulator; switched-capacitor circuits
资金
- National Institutes of Health
- National Institute of Aging
- National Science Foundation
- Defense Advanced Research Projects Agency
- Whitaker Foundation
A 16-channel current-measuring very large-scale integration (VLSI) sensor array system for highly sensitive electrochemical detection of electroactive neurotransmiters like dopamine and nitric-oxide is presented. Each channel embeds a current integrating potentiostat within a switched-capacitor first-order single-bit delta-sigma modulator implementing an incremental analog-to-digital converter. The duty-cycle modulation of current feedback in the delta-sigma loop together with variable oversampling ratio provide a programmable digital range selection of the input current spanning over six orders of magnitude from picoamperes to microamperes. The array offers 100-fA input current sensitivity at 3.4-mu W power consumption per channel. The operation of the 3 mm x 3 mm chip fabricated in 0.5-mu m CMOS technology is demonstrated with real-time multichannel acquisition of neurotransmitter concentration.
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