期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 21, 期 1, 页码 15-31出版社
BAILLIERE TINDALL
DOI: 10.1016/j.beem.2007.01.004
关键词
neuroendocrine tumours; classification; typing; staging; prognosis
The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroenteropancreatic compartment they are classified as well-differentiated neuroendocrine tumours or carcinomas and poorly differentiated neuroendocrine carcinomas. Depending on their localization these neoplasms reveal distinct phenotypes with respect to pathology, immunohistochemistry, and hormonal syndromes. Their clinical behaviour - ranging from benign and low-grade to high-grade malignancy - can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background.
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