期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 52, 期 42, 页码 10960-10985出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201301259
关键词
anticancer agent; biosynthesis; natural products; structure-activity relationships; total synthesis
资金
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft
- Ministry of Innovation, Science, and Research of the German federal state of North Rhine-Westphalia
- Heinrich-Heine- Universitat Dusseldorf
- Forschungszentrum Julich GmbH
Psymberin is a marine natural product which has attracted a great deal of interest since its isolation: While the highly cytotoxic compound was detected early on as an ingredient in a marine sponge, it took over a decade and 600 additional samples for the structure to eventually be assigned. In the last eight years fascinating synthetic and biosynthetic investigations have led to a more detailed understanding as well as a new starting point for structure-activity studies towards new antitumor compounds. The Review gives an in-depth insight into the progress in the field of the marine polyketide psymberin and demonstrates how organic synthesis is influencing neighboring scientific subjects.
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