期刊
MOLECULAR PHARMACEUTICS
卷 4, 期 2, 页码 189-198出版社
AMER CHEMICAL SOC
DOI: 10.1021/mp060045s
关键词
nanoparticles; cyclodextrin; DNA; gene transfection; cytotoxicity
A novel oligo(ethylenediamino)-beta-cyclodextrin-modified gold nanoparticle (OEA-CD-NP) was synthesized as a vector for DNA binding and comprehensively investigated by means of absorption and circular dichroism spectroscopies as well as transmission electron microscopy, and its plasmid transfection efficiency as a carrier into cultivated cells in vitro was also evaluated. Possessing many hydrophobic cavities at the outer space, OEA-CD-NP may have a capability of carrying biological and/or medicinal substrates into cells, which will make it potentially applicable in many fields of material science and biological technology. In contrast with OEA-CD-NP, the oligo(ethylenediamino)-lipoic amido-modified gold nanoparticle (OEA-L-NP) without CD was synthesized to investigate the interaction with DNA. The results showed that OEA-L-NPs could only weakly bind DNA.
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