期刊
INFECTION GENETICS AND EVOLUTION
卷 7, 期 2, 页码 254-262出版社
ELSEVIER
DOI: 10.1016/j.meegid.2006.10.004
关键词
hepatitis B virus; CTL selection; purifying selection; virus evolution
资金
- NCRR NIH HHS [RR016461] Funding Source: Medline
- NIGMS NIH HHS [R01 GM043940-18, R01 GM043940, GM43940] Funding Source: Medline
In hepatitis B virus (HBV), while mutations that escape from cytotoxic T-lymphocyte (CTL) recognition have been described it has been difficult to determine how natural selection by host CTL has influenced long-term evolution of HBV. We used statistical analysis of published HBV genomic sequences to examine the role of natural selection in evolution of CTL epitopes. Based on a phylogenetic analysis, we identified 25 pairs of closely related genomes isolated from different HBV genotypes and examined pattern of nucleotide substitution in genomic regions encoding well-characterized CTL epitopes. On average, both epitope and non-epitope regions are subject to purifying selection acting at non-synonymous sites. However, certain CTL epitopes showed a pattern of nucleotide substitution suggesting repeated positive selection across the population. The results support the hypothesis that CTL-driven selection has been an important factor in long-term evolution of HBV. (c) 2006 Published by Elsevier B.V.
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