期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 11, 期 2, 页码 200-205出版社
AMER CHEMICAL SOC
DOI: 10.1021/op060130d
关键词
-
1 alpha,25-Dihydroxyvitamin D-3 (calcitriol) 1 and synthetic analogues thereof are highly potent compounds with a wide range of pharmacological activity making them of great interest for the pharmaceutical industry. Herein we report an improved synthesis of the calcitriol analogue 2, which features a novel oxazole-containing side chain. The crucial part of the synthesis was the development of a practical route to the beta-keto phosphonate 28, allowing an easy introduction of the unnatural side chain by a Wittig Horner reaction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据