期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 71, 期 3, 页码 720-727出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.60563
关键词
okara; soybean residue; obesity; hepatocyte steatosis; lipid disorder
We examined the effect of okara on the prevention of obesity in mice. A modified AIN-76 diet with a high fat content (14.1 % of crude fat) was used as a basal diet. Male ICR mice were fed ad libitum with the basal diet or a dried okara-supplemented basal diet (10, 20, or 40%) for 10 weeks. The okara intake dose-dependently suppressed the development of body weight and epididymal white adipose tissue (EWAT), and prevented an increase of plasma lipids, including total cholesterol, LDL cholesterol, and non-esterified fatty acid. The okara intake also prevented steatosis in the liver. Real-time RT-PCR revealed that the okara intake induced down-regulation of the fatty acid synthetase gene and upregulation of the cholesterol 7 alpha-hydroxylase (CYP7AI) gene in the liver. We also found that the okara intake caused a marked reduction in the expression of leptin and TNF-alpha genes in EWAT. Our results suggest that okara is beneficial in preventing obesity.
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