期刊
MATRIX BIOLOGY
卷 26, 期 2, 页码 136-139出版社
ELSEVIER
DOI: 10.1016/j.matbio.2006.09.004
关键词
lysyl oxidase (LOX); epithelia; MDCK II cells; MCF-10A cells
资金
- NCRR NIH HHS [RR03061, G12 RR003061] Funding Source: Medline
- NIAMS NIH HHS [S11 AR047713-05, AR47662] Funding Source: Medline
- NIMHD NIH HHS [U54 MD007584] Funding Source: Medline
Considerable evidence supports novel functions for lysyl oxidase (LOX) beyond its traditional role in initiating cross-linkages in collagen and elastin within the extracellular matrix. These novel roles are particularly relevant during the transition of malignant epithelial cells towards a migratory and invasive phenotype. However, knowledge on cellular and matrix functions of LOX has been generated almost exclusively in mesenchymal cell types. But it is becoming increasingly evident that these cell types are not adequate to address these novel and highly significant roles for LOX in epithelial tissues. In this initial report, we demonstrate that active LOX is expressed by polarized MDCK II kidney and MCF-10A breast epithelial cells. Furthermore, we show evidence for the presence of mature LOX in the cytoplasm and establish these cell lines as models for epithelial LOX studies. (c) 2006 Elsevier B.V. /International Society of Matrix Biology. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据