期刊
PROSTATE CANCER AND PROSTATIC DISEASES
卷 10, 期 1, 页码 46-51出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.pcan.4500914
关键词
diabetes; insulin; VITAL; cohort; leptin; insulin-like growth factor
Epidemiologic evidence suggests diabetic men have a slightly lower prostate cancer risk than nondiabetic men. We examined this association in a prospective cohort study of 35 239 men, 50-76 years old, in Washington State who completed a baseline questionnaire between 2000 and 2002. Incident prostate cancers as of 31 December 2004 were identified through the SEER registry. Diabetic men had a slightly lower risk of prostate cancer than non-diabetic men ( hazard ratio (HR) 0.83, 95% confidence interval (CI) 0.64-1.07). Insulin users overall and insulin users with diabetic complications had decreased risks, compared to non-diabetic men ( HR 0.49, 95% CI 0.26-0.92) and ( HR 0.36, 95% CI 0.15-0.87), respectively. Oral medication use for diabetes was not associated with prostate cancer. Insulin is likely a marker of severity of diabetes. Future studies of this association should consider diabetes type, treatment, severity, complications and biomarkers.
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