期刊
ENVIRONMENTAL HEALTH PERSPECTIVES
卷 115, 期 3, 页码 483-492出版社
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
DOI: 10.1289/ehp.9786
关键词
adults; blood; bone; cognitive function; lead; neurobehavior
资金
- Intramural NIH HHS Funding Source: Medline
- NIA NIH HHS [R01 AG010785, R01 AG019604, R01-AG10785, R01-AG19604] Funding Source: Medline
- NIEHS NIH HHS [K01 ES012653, R01 ES005257-15, K01 ES012653-05, P42 ES005947, R01-ES10798, P30 ES000002, R01 ES010798, P30-ES00002, P42-ES05947, R01 ES007198, K01-ES012653, R01-ES07198, R01-ES05257, R01 ES005257] Funding Source: Medline
OBJECTIVE: We review empirical evidence for the relations of recent and cumulative lead dose with cog,nitive function in adults. DATA SOURCES: A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. DATA EXTRACTION: Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. CONCLUSIONS: At exposure levels encountered after environmental exposure, associations with biomarkers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults.
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