期刊
ARCHIVES OF NEUROLOGY
卷 64, 期 3, 页码 431-434出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archneur.64.3.431
关键词
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资金
- NIA NIH HHS [AG05134] Funding Source: Medline
- NIBIB NIH HHS [EB00768] Funding Source: Medline
- NINDS NIH HHS [NS038372] Funding Source: Medline
Objective: To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures of beta-amyloid (A beta) in postmortem tissue analysis. Patient: A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose F-18 and PiB positron emission tomographic brain scans. Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention: Autopsy was performed 3 months after the PiB scan. Results: Autopsy confirmed the clinical diagnosis; in addition, there was severe cerebral amyloid angiopathy and only moderate numbers of parenchymal A beta plaques. Biochemical measures revealed a positive correlation between A beta levels and regional PiB binding. Conclusion: This report confirms that PiB detects A beta in the living patient and demonstrates that amyloid deposited as cerebral amyloid angiopathy can be the dominant source of signal.
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