期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 51, 期 42, 页码 10472-10498出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201201114
关键词
cell recognition; cooperative phenomena; multivalency; receptors; supramolecular chemistry
资金
- Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center 765
Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptorligand interactions that are based on individually weak, noncovalent bonds and are thus generally reversible. Hence, multi- and polyvalent interactions play a decisive role in biological systems for recognition, adhesion, and signal processes. The scientific and practical realization of this principle will be demonstrated by the development of simple artificial and theoretical models, from natural systems to functional, application-oriented systems. In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.
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