期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 5, 页码 1326-1331出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.12.001
关键词
anti-ischemic agents; 1,4-benzodiazepin-2-ones; amino acids
A series of 3-substituted 1, 4-benzodiazepin-2-ones derived from S and R amino acids were evaluated for their anti-ischemic activity in vitro. Treatment with compounds 7h, 16, 9d, and 17 decreased the apoptotic neuronal number, however increased the neuronal viability. The compounds decreasing apoptosis could protect neurons from the ischemic injury. The difference in the activities of 1,4-benzodiazepin-2-ones derived from S- and R-amino acids is discussed and explained on the basis of molecular modeling studies. (c) 2006 Elsevier Ltd. All rights reserved.
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