期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 3, 页码 871-879出版社
WILEY
DOI: 10.1002/dvdy.21081
关键词
germ line; sex determination; cell number; RNA-binding protein
资金
- NIGMS NIH HHS [R01 GM069454, T32 GM007215, T32 GM07215] Funding Source: Medline
The specification of a germ cell as sperm or oocyte and determination of cell number remain unsolved questions in developmental biology. This paper examines Caenorhabditis elegans FOG-1, a CPEB-related RNA-binding protein that controls the sperm fate. We find that abundant FOG-1 protein is observed transiently in germ cells just prior to their expression of an early sperm-differentiation marker. As the germline tissue elongates, abundant FOG-1 appears more and more distally as sperm become specified, but disappears when the germ line switches to oogenesis. This dynamic pattern is controlled by both globally acting and germline-specific sex-determining regulators. Importantly, the extent of FOG-1 expression corresponds roughly to sperm number in wild-type and mutants, altering sperm number. By contrast, three other key regulators of the sperm/oocyte decision do not similarly correspond to sperm number. We suggest that FOG-1 is precisely modulated in both time and space to specify sperm fate and control sperm. number.
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