4.8 Article

Molecular Alliance - From Orthosteric and Allosteric Ligands to Dualsteric/Bitopic Agonists at G Protein Coupled Receptors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Pharmacology & Pharmacy

The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein-Coupled Receptors

Celine Valant et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)

Review Pharmacology & Pharmacy

Pharmacological modulation of chemokine receptor function

D. J. Scholten et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Pharmacology & Pharmacy

Biased signalling and allosteric machines: new vistas and challenges for drug discovery

Terry P. Kenakin

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Multidisciplinary Sciences

Structure of the δ-opioid receptor bound to naltrindole

Sebastien Granier et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

Kazuko Haga et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure of the human κ-opioid receptor in complex with JDTic

Huixian Wu et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Aaron A. Thompson et al.

NATURE (2012)

Article Multidisciplinary Sciences

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Aashish Manglik et al.

NATURE (2012)

Article Multidisciplinary Sciences

Structure and dynamics of the M3 muscarinic acetylcholine receptor

Andrew C. Kruse et al.

NATURE (2012)

Review Pharmacology & Pharmacy

Domain coupling in GPCRs: the engine for induced conformational changes

Hamiyet Unal et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Review Pharmacology & Pharmacy

Structure-based drug screening for G-protein-coupled receptors

Brian K. Shoichet et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Review Pharmacology & Pharmacy

Diversity and modularity of G protein-coupled receptor structures

Vsevolod Katritch et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Article Multidisciplinary Sciences

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

Andreas Bock et al.

NATURE COMMUNICATIONS (2012)

Editorial Material Chemistry, Multidisciplinary

The Golden Age of GPCR Structural Biology: Any Impact on Drug Design?

Peter Kolb et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Pharmacology & Pharmacy

Strategies for the identification of allosteric modulators of G-protein-coupled receptors

Neil T. Burford et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Molecular Switches on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

Michael R. Wood et al.

BIOCHEMISTRY (2011)

Review Chemistry, Medicinal

Design Strategies for Bivalent Ligands Targeting GPCRs

Jeremy Shonberg et al.

CHEMMEDCHEM (2011)

Article Chemistry, Medicinal

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

W. Patrick Walters et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Structure of the human histamine H1 receptor complex with doxepin

Tatsuro Shimamura et al.

NATURE (2011)

Article Multidisciplinary Sciences

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Multidisciplinary Sciences

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Daniel M. Rosenbaum et al.

NATURE (2011)

Article Multidisciplinary Sciences

Pathway and mechanism of drug binding to G-protein-coupled receptors

Ron O. Dror et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Allostery in pharmacology: Thermodynamics, evolution and design

Gabor Maksay

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)

Review Pharmacology & Pharmacy

Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

M. C. Peeters et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Review Pharmacology & Pharmacy

GPCR agonist binding revealed by modeling and crystallography

Vsevolod Katritch et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2011)

Review Biochemistry & Molecular Biology

Molecular obesity, potency and other addictions in drug discovery

Michael M. Hann

MEDCHEMCOMM (2011)

Review Pharmacology & Pharmacy

Allosteric Receptors: From Electric Organ to Cognition

Jean-Pierre Changeux

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2010)

Review Pharmacology & Pharmacy

Rational design of dualsteric GPCR ligands: quests and promise

Klaus Mohr et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Chemistry, Medicinal

Hybrid Ortho/Allosteric Ligands for the Adenosine A1 Receptor

Rajeshwar Narlawar et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders

Gregory J. Digby et al.

MOLECULAR BIOSYSTEMS (2010)

Article Multidisciplinary Sciences

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Ellen Y. T. Chien et al.

SCIENCE (2010)

Article Chemistry, Medicinal

A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors

Shijun Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Article Biochemistry & Molecular Biology

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

Johannes Antony et al.

FASEB JOURNAL (2009)

Review Multidisciplinary Sciences

The structure and function of G-protein-coupled receptors

Daniel M. Rosenbaum et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

P. Jeffrey Conn et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Medicine, General & Internal

Cinacalcet -: an allosteric enhancer at the Ca2+-receptor

A. Kebig et al.

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT (2008)

Article Multidisciplinary Sciences

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

Veli-Pekka Jaakola et al.

SCIENCE (2008)

Article Biochemistry & Molecular Biology

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

Dorothea Jaeger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

Crystal structure of the human β2 adrenergic G-protein-coupled receptor

Soren G. F. Rasmussen et al.

NATURE (2007)

Review Pharmacology & Pharmacy

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

Thue W. Schwartz et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Article Multidisciplinary Sciences

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

DJ Daniels et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biotechnology & Applied Microbiology

Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery

A Christopoulos

NATURE REVIEWS DRUG DISCOVERY (2002)

Article Pharmacology & Pharmacy

A new benzodiazepine pharmacology

H Mohler et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)