期刊
EUKARYOTIC CELL
卷 6, 期 3, 页码 388-397出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00366-06
关键词
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资金
- NIGMS NIH HHS [R01 GM026973, GM-26973] Funding Source: Medline
Glycylation is an uncommon posttranslational modification. It has been found that tubulin glycylation is essential for cell survival in Tetrahymena. Here we describe PGP1, a Tetrahymena gene encoding an Hsp70 homologue that is a novel glycylated protein. Pgp1p is a conserved glycoprotein that localizes within the lumen of the endoplasmic reticulum (ER). We demonstrate that PGP1 is essential for viability and present evidence that both glycosylation and ER retention are necessary but not sufficient for glycylation.
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