期刊
HUMAN GENETICS
卷 121, 期 1, 页码 145-148出版社
SPRINGER
DOI: 10.1007/s00439-006-0286-y
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资金
- NHLBI NIH HHS [HV48141] Funding Source: Medline
- NIAMS NIH HHS [R01 AR45349-01, K01 AR021170-01] Funding Source: Medline
- NIGMS NIH HHS [R01 GM60402-01A1] Funding Source: Medline
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
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