期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 25, 期 5, 页码 1599-1603出版社
WILEY
DOI: 10.1111/j.1460-9568.2007.05380.x
关键词
ACTH; amygdala; elevated platform; maternal defence; NGFIB; paraventricular nucleus
资金
- Wellcome Trust Funding Source: Medline
Hypothalamo-pituitary-adrenal axis responses to various stressors are typically attenuated during lactation, including in rats selectively bred for high or low anxiety. As high-anxiety dams are more aggressive towards intruders than low-anxiety dams during maternal defence, we investigated their hypothalamo-pituitary-adrenal axis responses to this social stress. Maternal defence induced elevated stress responses in high-anxiety dams only; nerve-growth-factor-induced gene B mRNA expression in the parvocellular paraventricular nucleus and adrenocorticotropin hormone secretory responses were substantially enhanced after maternal defence. In contrast, secretory responses to a non-social stress (elevated platform) were not different between high- and low-anxiety dams. Thus, responsiveness of the stress axis in lactation is dependent upon the innate level of anxiety of the dam and, as a consequence, her reactiveness to social threat.
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