期刊
GENETIC TESTING
卷 11, 期 1, 页码 55-64出版社
MARY ANN LIEBERT INC
DOI: 10.1089/gte.2006.0512
关键词
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资金
- NCRR NIH HHS [M01 RR10284, 5 M01 RR00827-29, M01 RR00032] Funding Source: Medline
- NHLBI NIH HHS [N01 HC 05189, UH1 HL03679-05, N01 HC 05190, N01 HC 05188, N01 HC 05186, N01 HC 05192, N01 HC 05191, N01 HC 05185] Funding Source: Medline
The Hemochromatosis and Iron Overload Screening (HEIRS) Study screened 101,168 participants recruited from primary-care clinics in Canada and the United States. The present study investigated differences in the psychological effects of genetic screening for hemochromatosis (HFE mutation analysis) in participants from each country. Study participants comprised a subset of 2,654 individuals who donated blood for HFE mutation analysis. The initial screening and 1-month post-result questionnaires included measures of General Health, Mental Health (SF-36), and a measure of the percentage of individuals who experienced at least one example of worry in response to the genetic testing. Participants reported similar changes in general health and mental health, regardless of mutation result, or country. Although a significantly lower percentage of Canadian participants than U. S. participants indicated at least one negative emotional response to the genetic testing, greater than 50% of C282Y homozygote participants (the gene mutation most strongly associated with hemochromatosis) from both countries experienced such in response to testing. Thus, although not serious enough to affect individuals' mental or physical health, there was evidence of at least one element of negative emotional response to the genetic testing. These findings suggest that population screening for common HFE mutations associated with hemochromatosis risk has similar psychological effects on Canadian and U. S. individuals, although fewer Canadians may experience a negative response to such testing.
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