期刊
EXPERIMENTAL GERONTOLOGY
卷 42, 期 3, 页码 247-251出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.10.009
关键词
diet restriction; calorie restriction; nutrition; aging; life span; Drosophila melanogaster
资金
- NIA NIH HHS [R01 AG021953, R01 AG024360] Funding Source: Medline
The extension of life span by diet restriction in Drosophila has been argued to occur without limiting calories. Here we directly measure the calories assimilated by flies when maintained on full- and restricted-diets. We find that caloric intake is reduced on all diets that extend life span. Flies on low-yeast diet are long-lived and consume about half the calories of flies on high-yeast diets, regardless of the energetic content of the diet itself. Since caloric intake correlates with yeast concentration and thus with the intake of every metabolite in this dietary component, it is premature to conclude for Drosophila that calories do not explain extension of life span. (c) 2006 Elsevier Inc. All rights reserved.
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