期刊
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
卷 66, 期 4, 页码 761-765出版社
WILEY
DOI: 10.1002/prot.21281
关键词
date hub; party hub; intrinsic disorder; transient interaction; reversible interaction
Hubs in the protein-protein interaction network have been classified as party hubs, which are highly correlated in their mRNA expression with their partners while date hubs show lesser correlation. In this study, we explored the role of intrinsic disorder in date and party hub interactions. The data reveals that intrinsic disorder is significantly enriched in date hub proteins when compared with party hub proteins. Intrinsic disorder has been largely implicated in transient binding interactions. The disorder to order transition, which occurs during binding interactions in disordered regions, renders the interaction highly reversible while maintaining the high specificity. The enrichment of intrinsic disorder in date hubs may facilitate transient interactions, which might be required for date hubs to interact with different partners at different times.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据