期刊
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
卷 102, 期 477, 页码 93-103出版社
AMER STATISTICAL ASSOC
DOI: 10.1198/016214506000001211
关键词
correlated processes; empirical null; false discovery rate; microarray
Large-scale hypothesis testing problems, with hundreds or thousands of test statistics z(i) to consider at once, have become familiar in current practice. Applications of popular analysis methods, such as false discovery rate techniques, do not require independence of the z(i)'s, but their accuracy can be compromised in high-correlation situations. This article presents computational and theoretical methods for assessing the size and effect of correlation in large-scale testing. A simple theory leads to the identification of a single omnibus measure of correlation for the z(i)'s order statistic. The theory relates to the correct choice of a null distribution for simultaneous significance testing and its effect on inference.
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