期刊
BIOLOGICAL PSYCHIATRY
卷 61, 期 5, 页码 591-598出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.04.011
关键词
basolateral amygdala; drug seeking; glutamate; reinstatement; relapse
资金
- Intramural NIH HHS Funding Source: Medline
Background: We and others reported time-dependent increases in cue-induced cocaine seeking after withdrawal, suggesting that craving incubates overtime. Recently, we found that central amygdala extracellular signal-regulated kinases (ERK) and glutamate are involved in this incubation. Here, we further explored the role of central amygdala glutamate in the incubation of cocaine craving by determining the effect of systemic or central amygdala injections of the mGluR(2/3) agonist LY379268 (which decreases glutamate release) on cue-induced cocaine seeking during early and late withdrawal. Methods: Rats were trained to self-administer cocaine for 10 days (6 hours/day); infusions were paired with a tone-light cue. Cocaine seeking and craving after systemic or central amygdala injections of LY379268 were then assessed in extinction tests in the presence of the cocaine-associated cues during early (day 3) or late (day 21) withdrawal. Results: Systemic (1.5 or 3 mg/kg) or central amygdala (.5 or 1.0 mu g/side) injections of LY379268 attenuated enhanced extinction responding on day 21 but had no effect on lower extinction responding on day 3. Conclusions: Results confirm our previous findings on the role of central amygdala glutamate in the incubation of cocaine craving and together with previous reports suggest that mGluR(2/3), agonists should be considered in the treatment of drug relapse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据