期刊
JOURNAL OF VIROLOGY
卷 81, 期 6, 页码 2995-2998出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02486-06
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- NIAID NIH HHS [1U54 AI 057153, U54 AI057153] Funding Source: Medline
Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable differences in disease progression, hematology, serum biochemistry, virus titers, or lethality in nonhuman primates infected with an Ebola virus lacking the furin recognition sequence compared to those infected with wild-type virus. We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates.
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