期刊
INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
卷 21, 期 3, 页码 241-250出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/2049396714Y.0000000102
关键词
Chronic kidney disease; Mesoamerican Nephropathy; Chronic kidney disease of nontraditional etiology; Estimated glomerular filtration rate; Serum creatinine; Tubulointerstitial
资金
- Compliance Advisor/Ombudsman (CAO), the independent accountability mechanism for social and environmental issues of IFC/MIGA of the World Bank Group
- Comite Nacional de Productores de Azucar (CNPA)
- Enrique Najera predoctoral grant - Spanish Society of Epidemiology
- Instituto de Salud Carlos III
- National Institutes of Health [T32 ES014562]
- STAR Fellowship Assistance - U.S. Environmental Protection Agency (EPA) [FP-91764901-0]
Background: There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers. Objectives: To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria. Methods: We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR). Results: eGFR varied by job and decreased during the harvest in seed cutters (28.6 ml/min/1.73 m(2)), irrigators (27.4 ml/min/1.73 m(2)), and cane cutters (25.0 ml/min/1.73 m(2)), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR).30 mg/g. Conclusions: The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.
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