A new bioactive prenylated dihydroflavanoid from Dolichos tenuicaulis (Baker) Craib

A new prenylated dihydroflavonoid was obtained from the root of Dolichos tenuicaulis (Baker) Craib. The structure was elucidated as (2S)-5,2',6'-trihydroxy-3 ''', 8-di (gamma, gamma-dimethyl-allyl)-2''', 2'''-dimethylpyrano-[5''',6''': 6,7]-2''''',4'''''-cyclohexadiene-1'''''-one-[''''',3''''': 3',4']-flavanone, named dolichnin A, by spectroscopic methods including UV, IR, HR-EI-MS, ID NMR and 2D NMR techniques, and subsequently, the anticancer activity of this compound to inhibit human cancer cells' growth including A549, BEL-7402, Hep-3B, SMMC7721, HT-29, MCF-7, SGC-7902, K562, A498 and PC3 cell lines by MTT method was evaluated in vitro. (c) 2007 Jin Yong Peng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.