期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 33, 期 3, 页码 245-253出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040601150195
关键词
phase solubility; quercetin; rutin; CD; dissolution; physicochemical characterization
The objective of the present study is to prepare and characterize cyclodextrin inclusion complexes of quercetin and rutin to improve their aqueous solubility and dissolution properties. Inclusion complexes of quercetin and rutin with beta-cyclodextrin (beta-CD) and hydroxyl propyl-beta-cyclodextrin (HP-beta-CD) were prepared by kneading and coevaporation methods. Characterization of inclusion complexes was done by phase solubility analysis and was supported by X-ray powder diffractometry (XRD), differential scanning calorimetry (DSC), and Fourier-transform infra red spectroscopy (FT-IR) analysis. Inclusion complexes exhibited higher rates of dissolution than the corresponding physical mixtures and pure drug. Higher dissolution rates were observed with HP-beta-CD kneaded complexes in comparison to the products with S-CD.
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