期刊
VETERINARY OPHTHALMOLOGY
卷 10, 期 2, 页码 69-75出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1463-5224.2007.00503.x
关键词
cone-rod dystrophy; dog; electroretinography; maze test; pupillary light reflexes; retinal degeneration
Objective To describe the clinical findings and the age of onset of cone-rod dystrophy (crd) in the Standard Wire-haired Dachshund (SWHD) and to evaluate which clinical tests could be used to obtain a reliable diagnosis. Animals Sixry-eight SWHD and SWHD-derived dogs were used, including 23 affected with crd and 45 controls, respectively. Procedures The dogs were subjected to behavioral testing, examination of pupillary light reflexes (PLRs), indirect oplithalmoscopy and bilateral full field electroretinography (ERG). Results The majoritv of affected puppies (5-10 weeks) displayed pin-point sized pupils upon examination with focal light. All dogs in the control group, except one, displayed normal PLRs upon examination. In all crd-affected dogs there was a great variation both in age of onset and in clinical appearance of retinal changes upon fundoscopy. Two siblings displayed panretinal degeneration at the age of 10 months while other affected dogs showed early changes at the age of 3 years. Generalized bilateral retinal atrophy was the end stage of the disease. The maze test revealed no obvious differences among affected and unaffected groups. ERG recordings showed only slightly reduced rod, and mixed rod-cone responses, but severely reduced cone single flash a- and b-wave amplitudes, and cone flicker amplitudes were observed in all affected dogs. Conclusion Presence of pin-point sized pupils in young SWHDs was found to be an important indicator of early onset crd. Fundoscopic changes and progression of disease at later stages resembled those previously described in the majority of progressive retinal atrophies in dog. ERG was found to be the most reliable diagnostic procedure to clinically diagnose crd in the SWHD.
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