期刊
BREAST JOURNAL
卷 13, 期 2, 页码 189-191出版社
WILEY
DOI: 10.1111/j.1524-4741.2007.00398.x
关键词
nonislet cell tumor hypoglycemia; phyllodes tumor; breast cancer; insulin-like growth factor II; big insulin-like growth factor II
Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
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